Home/ Products / Recombinant Rabbit McAbs
DMR1384-100ug
100 ug
$657
DMR1384-500ug
500 ug
$1,971
This recombinant rabbit monoclonal antibody is part of a collection of rabbit mAbs against druggable targets developed by direct cloning from immunized rabbit B cells without hybridoma fusion. All antibodies have been fully sequenced and extensively validated by FACS and ELISA assays. Typically, multiple clones against each target are available for customer testing. The clones are available for licensing once the druggability of the antibodies has been validated by the customer, saving tremendous development time and effort. Antibody gene libraries from antigen-positive B cells are also available for further screening if the listed antibodies do not meet the customer's needs.
This bispecific antibody is an engineered fusion protein comprised of an anti-CD3 scFv and an anti-BCMA scFv.
| target | TNFRSF17 |
| alias | TNFRSF17 |
| gene id | Uniprot ID: Q02223 |
| host species | Rabbit |
| production host | HEK293 |
| reactivity | Human |
| clonality | Monoclonal |
| clone number | DM4 |
| iso type | Rabbit scfv |
| formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. |
| reconstitution | Reconstitute lyophilized powder with water to a concentration of 100 ug/ml, solubilize at RT for 30 min with occasional gentle mixing. It is recommended that 0.1% of HSA be added as a carrier protein for long term storage. |
| applications | Flow Cytometry, MM Tumor cell killing |
| dilution | Flow Cyt 1:100; MMTumor cell killing |
| shipping | Shipped at ambient conditions. |
| storage | Lyophilized form is stable for 1 week at room temperature. Store at -20 °C to -80 °C for 12 months in lyophilized form. After reconstitution, store at 4 °C for 2-7 days or at below -20 °C for up to 3 months. |
The basic principle of BiTE cell killing assay. The BiTE molecule can effectively bring T cells to tumor target cells and stimulate tumor cell killing activity of T cells.
A: The scheme of anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase), were incubated with freshly isolated human PBMC, and different concentration of BiTE antibodies constructed from rabbit anti-Human BCMA/TNFRSF17 Clone DM4 (red line), or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation, the viable NCI-H929 tumor cells were measured by luciferase activity assay.
DMR1384-100ug
100 ug
$657
DMR1384-500ug
500 ug
$1,971